Preclinical development of a first-in-class vaccine encoding HER2, Brachyury and CD40L for antibody enhanced tumor eradication
Abstract The induction fr5947 of antiviral innate immunity by systemic immunization with live virus can be employed to positively impact the response to therapeutic vaccination.We previously demonstrated that systemic immunization with a non-replicating MVA encoding CD40 ligand (CD40L) enhances innate immune cell activation and function, and trigge