PRECLINICAL DEVELOPMENT OF A FIRST-IN-CLASS VACCINE ENCODING HER2, BRACHYURY AND CD40L FOR ANTIBODY ENHANCED TUMOR ERADICATION

Preclinical development of a first-in-class vaccine encoding HER2, Brachyury and CD40L for antibody enhanced tumor eradication

Abstract The induction fr5947 of antiviral innate immunity by systemic immunization with live virus can be employed to positively impact the response to therapeutic vaccination.We previously demonstrated that systemic immunization with a non-replicating MVA encoding CD40 ligand (CD40L) enhances innate immune cell activation and function, and trigge

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Localization and tissue tropism of the symbiont Microsporidia MB in the germ line and somatic tissues of Anopheles arabiensis

ABSTRACTThe Anopheles symbiont, Microsporidia MB, is maternally inherited and has a strong malaria transmission-blocking phenotype in Anopheles arabiensis.Microsporidia MB is also vertically transmitted, sexually transmitted, and avirulent.These characteristics are expected to promote its spread through mosquito populations, enhancing the potential

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